Version 5.4
Homo sapiens Gene: CEACAM8
Summary
InnateDB Gene IDBG-54589.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEACAM8
Gene Name carcinoembryonic antigen-related cell adhesion molecule 8
Synonyms CD66b; CD67; CGM6; NCA-95
Species Homo sapiens
Ensembl Gene ENSG00000124469
Encoded Proteins
IDBP-54591
carcinoembryonic antigen-related cell adhesion molecule 8
IDBP-765526
IDBP-811790
carcinoembryonic antigen-related cell adhesion molecule 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26176669
Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:42580241-42740384
Strand Reverse strand
Band q13.2
Transcripts
ENST00000244336 ENSP00000244336
ENST00000599005 ENSP00000472166
ENST00000614151 ENSP00000484915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0031225 anchored component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_160131
Fibronectin matrix formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1088
UniGene
RefSeq NM_001816 XM_005258433
HUGO HGNC:1820
OMIM 114890 615747
CCDS CCDS12610
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 1088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca