Version 5.4
Homo sapiens Gene: PSMA1
Summary
InnateDB Gene IDBG-545891.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMA1
Gene Name proteasome subunit alpha type-1 isoform 3
Synonyms HC2; HEL-S-275; NU; PROS30
Species Homo sapiens
Ensembl Gene ENSG00000256206
Encoded Proteins
IDBP-719096
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:14493783-14520344
Strand Reverse strand
Band p15.2
Transcripts
ENST00000555531 ENSP00000457299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
Experimentally validated
Total 135 [view]
Protein-Protein 135 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa03050
Proteasome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B4DEV8
UniProt Splice Variant
Entrez Gene 5682
UniGene
RefSeq
HUGO
OMIM 602854
CCDS
HPRD
IMGT
EMBL AC018523 AC087207 AK293813
GenPept BAG57219
RNA Seq Atlas 5682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca