Version 5.4
| Homo sapiens Gene: KLRK1 | |||
|---|---|---|---|
| Summary | |||
| InnateDB Gene | IDBG-546188.3 | ||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||
| Gene Symbol | KLRK1 | ||
| Gene Name | NKG2-D type II integral membrane protein | ||
| Synonyms | CD314; D12S2489E; KLR; NKG2-D; NKG2D | ||
| Species | Homo sapiens | ||
| Ensembl Gene | ENSG00000255819 | ||
| Encoded Proteins |
KLRC4-KLRK1 readthrough
|
||
| Protein Structure | |||
| Useful resources | Stemformatics EHFPI ImmGen | ||
| Entrez Gene | |||
| Summary |
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010] |
||
| Gene Information | |||
| Type | Protein coding | ||
| Genomic Location | Chromosome 12:10372353-10410146 | ||
| Strand | Reverse strand | ||
| Band | p13.2 | ||
| Transcripts | |||
| Interactions | |||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||
| Orthologs | |||
| No orthologs found for this gene | |||
| Pathways | |||
| NETPATH | |||
| REACTOME | |||
| KEGG |
Natural killer cell mediated cytotoxicity pathway
Malaria pathway
|
||
| INOH | |||
| PID NCI | |||
| Cross-References | |||
| SwissProt | |||
| TrEMBL | H3BRK7 H3BU71 | ||
| UniProt Splice Variant | |||
| Entrez Gene | 22914 | ||
| UniGene | Hs.721094 Hs.722283 | ||
| RefSeq | NM_001199805 | ||
| HUGO | HGNC:48357 | ||
| OMIM | 611817 | ||
| CCDS | CCDS8623 | ||
| HPRD | |||
| IMGT | |||
| EMBL | AC022075 | ||
| GenPept | |||
| RNA Seq Atlas | 100528032 22914 | ||