Version 5.4
Homo sapiens Gene: ARHGAP25
Summary
InnateDB Gene IDBG-54649.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP25
Gene Name Rho GTPase activating protein 25
Synonyms HEL-S-308; KAIA0053
Species Homo sapiens
Ensembl Gene ENSG00000163219
Encoded Proteins
IDBP-295690
Rho GTPase activating protein 25
IDBP-295693
Rho GTPase activating protein 25
IDBP-295692
Rho GTPase activating protein 25
IDBP-484671
Rho GTPase activating protein 25
IDBP-485345
Rho GTPase activating protein 25
IDBP-480465
Rho GTPase activating protein 25
IDBP-476326
Rho GTPase activating protein 25
IDBP-485342
Rho GTPase activating protein 25
IDBP-481071
Rho GTPase activating protein 25
IDBP-476331
Rho GTPase activating protein 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:68679601-68826833
Strand Forward strand
Band p13.3
Transcripts
ENST00000409202 ENSP00000386911
ENST00000409030 ENSP00000386863
ENST00000409220 ENSP00000386241
ENST00000456116
ENST00000463483 ENSP00000417283
ENST00000481684
ENST00000491237
ENST00000467265 ENSP00000420583
ENST00000485573
ENST00000488795 ENSP00000420427
ENST00000463061
ENST00000485700
ENST00000496266
ENST00000473986 ENSP00000417425
ENST00000497079 ENSP00000417139
ENST00000497259 ENSP00000417818
ENST00000479844 ENSP00000417467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030047
View Gene Order
ENSBTAG00000023976
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.531807 Hs.740143
RefSeq NM_001007231 NM_001166276 NM_001166277 NM_014882 XM_005264675
HUGO
OMIM
CCDS CCDS33214 CCDS46312 CCDS54363 CCDS54364
HPRD 09805
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca