Version 5.4
Homo sapiens Gene: IGLL5
Summary
InnateDB Gene IDBG-547140.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGLL5
Gene Name immunoglobulin lambda-like polypeptide 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000254709
Encoded Proteins
IDBP-588932
immunoglobulin lambda-like polypeptide 5
IDBP-588035
immunoglobulin lambda-like polypeptide 5
IDBP-603621
immunoglobulin lambda-like polypeptide 5
IDBP-808123
immunoglobulin lambda-like polypeptide 5
IDBP-808126
immunoglobulin lambda-like polypeptide 5
IDBP-808130
immunoglobulin lambda-like polypeptide 5
IDBP-808135
immunoglobulin lambda-like polypeptide 5
IDBP-808136
immunoglobulin lambda-like polypeptide 5
IDBP-808138
immunoglobulin lambda-like polypeptide 5
IDBP-808139
immunoglobulin lambda-like polypeptide 5
IDBP-808141
immunoglobulin lambda-like polypeptide 5
IDBP-808143
immunoglobulin lambda-like polypeptide 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:22734620-22896107
Strand Forward strand
Band q11.22
Transcripts
ENST00000532223 ENSP00000436353
ENST00000526893 ENSP00000431254
ENST00000531372 ENSP00000434368
ENST00000613777 ENSP00000480721
ENST00000620657 ENSP00000478359
ENST00000621800 ENSP00000482028
ENST00000616131 ENSP00000480497
ENST00000617866 ENSP00000480121
ENST00000617880 ENSP00000481964
ENST00000610541 ENSP00000480892
ENST00000620665 ENSP00000480519
ENST00000612695 ENSP00000484805
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000075370
View Gene Order
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_160274
FCGR activation pathway
REACT_7956
Classical antibody-mediated complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_160163
Scavenging of heme from plasma pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_8012
Creation of C4 and C2 activators pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_6932
Complement cascade pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
INOH
INOH website
B cell receptor signaling pathway
PID NCI
Cross-References
SwissProt P0CG04
TrEMBL A0M8Q9
UniProt Splice Variant
Entrez Gene 100423062
UniGene
RefSeq NM_001178126 NM_001256296
HUGO HGNC:38476
OMIM 147220
CCDS CCDS54506
HPRD
IMGT
EMBL CH471095 D87023 J00252 X51755
GenPept AAA59106 BAA20024 CAA36047 EAW59545
RNA Seq Atlas 100423062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca