Version 5.4
Homo sapiens Gene: RNASE4
Summary
InnateDB Gene IDBG-547170.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE4
Gene Name ribonuclease 4 precursor
Synonyms RAB1; RNS4
Species Homo sapiens
Ensembl Gene ENSG00000258818
Encoded Proteins
IDBP-234113
Ribonuclease 4
IDBP-589857
Ribonuclease 4
IDBP-583202
Ribonuclease 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3\' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5\' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20684100-20701215
Strand Forward strand
Band q11.2
Transcripts
ENST00000397995 ENSP00000381081
ENST00000555835 ENSP00000452245
ENST00000555597 ENSP00000451624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004522 pancreatic ribonuclease activity
Biological Process
GO:0006379 mRNA cleavage
GO:0009267 cellular response to starvation
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021876
View Gene Order
ENSBTAG00000019612
Not yet available
Cross-References
SwissProt P34096
TrEMBL Q53XB4
UniProt Splice Variant
Entrez Gene 6038
UniGene Hs.283749 Hs.730830
RefSeq NM_001282192 NM_001282193 NM_002937 NM_194431
HUGO HGNC:10047
OMIM 601030
CCDS CCDS9555
HPRD 03018
IMGT
EMBL AK092422 BC015520 BX247985 BX248010 CH471078 D37931 HG328836 U36775
GenPept AAA96750 AAH15520 BAA07150 BAG52550 CAD62319 CAD62338 CDG31912 EAW66448
RNA Seq Atlas 6038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca