InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GFPT1

Summary

InnateDB Gene

IDBG-54824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFPT1

Gene Name

glutamine--fructose-6-phosphate transaminase 1

Synonyms

CMSTA1; GFA; GFAT; GFAT 1; GFAT1; GFAT1m; GFPT; GFPT1L; MSLG

Species

Homo sapiens

Ensembl Gene

ENSG00000198380

Encoded Proteins

IDBP-54826

glutamine--fructose-6-phosphate transaminase 1

IDBP-54828

glutamine--fructose-6-phosphate transaminase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:69319769-69387254

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000357308	ENSP00000349860
ENST00000361060	ENSP00000354347
ENST00000493759
ENST00000494201

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0016597	amino acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006042	glucosamine biosynthetic process
GO:0006047	UDP-N-acetylglucosamine metabolic process
GO:0006048	UDP-N-acetylglucosamine biosynthetic process
GO:0006112	energy reserve metabolic process
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0006541	glutamine metabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0008152	metabolic process
GO:0009744	response to sucrose stimulus
GO:0016051	carbohydrate biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0032922	circadian regulation of gene expression
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0051289	protein homotetramerization