Homo sapiens Gene: NOP10
Summary
InnateDB Gene IDBG-5501.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol NOP10
Gene Name NOP10 ribonucleoprotein homolog (yeast)
Synonyms DKCB1; NOLA3; NOP10P;
Species Homo sapiens
Ensembl Gene ENSG00000182117
Encoded Proteins
NOP10 ribonucleoprotein homolog (yeast)
NOP10 ribonucleoprotein homolog (yeast)
Protein Structure
Entrez Gene
Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:34633917-34635378
Strand Reverse strand
Band q14
Transcripts
ENST00000328848 ENSP00000332198
ENST00000557912 ENSP00000453475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
Cellular Component
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0015030 Cajal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NPE3
TrEMBL H0YM60
UniProt Splice Variant
Entrez Gene 55505
UniGene
RefSeq NM_018648
HUGO 14378
OMIM 606471
CCDS CCDS10037
HPRD 07571
IMGT
EMBL AB043103 AB043104 AC021822 BC008886 BC063023
GenPept AAH08886 AAH63023 BAA96107 BAA96133
ImmGen NOP10 (murine)
RNA Seq Atlas 55505