Homo sapiens Gene: NOP10

Summary
InnateDB Gene IDBG-5501.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol NOP10
Gene Name NOP10 ribonucleoprotein homolog (yeast)
Synonyms DKCB1; NOLA3; NOP10P
Species Homo sapiens
Ensembl Gene ENSG00000182117
Encoded Proteins
IDBP-5503 NOP10 ribonucleoprotein homolog (yeast)
IDBP-592920 NOP10 ribonucleoprotein homolog (yeast)
Entrez Gene
Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15: 34633917-34635378
Strand Reverse strand
Band q14
Transcripts
ENST00000328848  ENSP00000332198
ENST00000557912  ENSP00000453475
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein‑Protein  3
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
Cellular Component
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0015030 Cajal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000027133 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000025632 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
hsa03013  RNA transport
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NPE3 
TrEMBL H0YM60
UniProt Splice Variant
Entrez Gene 55505 
UniGene
RefSeq NM_018648 
HUGO 14378 
OMIM 606471
CCDS CCDS10037 
HPRD 07571
IMGT
EMBL AB043103 AB043104 AC021822 BC008886 BC063023
GenPept AAH08886  AAH63023  BAA96107  BAA96133 
ImmGen NOP10 (murine) 
RNA Seq Atlas 55505