Version 5.4
Homo sapiens Gene: SEPHS1
Summary
InnateDB Gene IDBG-55020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPHS1
Gene Name selenophosphate synthetase 1
Synonyms SELD; SPS; SPS1
Species Homo sapiens
Ensembl Gene ENSG00000086475
Encoded Proteins
IDBP-55022
selenophosphate synthetase 1
IDBP-55026
selenophosphate synthetase 1
IDBP-366336
selenophosphate synthetase 1
IDBP-366338
selenophosphate synthetase 1
IDBP-598423
selenophosphate synthetase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:13317424-13348298
Strand Reverse strand
Band p13
Transcripts
ENST00000327347 ENSP00000367893
ENST00000378614 ENSP00000367877
ENST00000413411 ENSP00000401732
ENST00000425947 ENSP00000400418
ENST00000494329
ENST00000545675 ENSP00000441119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004756 selenide, water dikinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006464 cellular protein modification process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026662
View Gene Order
ENSBTAG00000008821
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.124027 Hs.528583 Hs.610736 Hs.633638
RefSeq NM_001195602 NM_001195604 NM_012247 XM_006717433
HUGO
OMIM
CCDS CCDS55702 CCDS55703 CCDS7098
HPRD 02944
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca