InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP4K2

Summary

InnateDB Gene

IDBG-55181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K2

Gene Name

mitogen-activated protein kinase kinase kinase kinase 2

Synonyms

BL44; GCK; RAB8IP

Species

Homo sapiens

Ensembl Gene

ENSG00000168067

Encoded Proteins

IDBP-55185

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-55187

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-377797

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-377804

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-377817

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-377821

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-377823

mitogen-activated protein kinase kinase kinase kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:64788818-64803241

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000377350	ENSP00000366567
ENST00000294066	ENSP00000294066
ENST00000435926	ENSP00000400594
ENST00000424945	ENSP00000403410
ENST00000433890	ENSP00000413167
ENST00000439069	ENSP00000403563
ENST00000444560	ENSP00000404534
ENST00000470088
ENST00000489952
ENST00000467689
ENST00000493428
ENST00000482314
ENST00000468062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0006903	vesicle targeting
GO:0006955	immune response
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0000139	Golgi membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024948

View Gene Order

ENSBTAG00000001037

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

Cross-References

SwissProt

TrEMBL

F2Z2B3

UniProt Splice Variant

Entrez Gene

5871

UniGene

Hs.534341

RefSeq

NM_004579

HUGO

HGNC:6864

OMIM

603166

CCDS

CCDS8082

HPRD

04408

IMGT

EMBL

AP001462

GenPept

RNA Seq Atlas

5871