Version 5.4
Homo sapiens Gene: CYFIP2
Summary
InnateDB Gene IDBG-55402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYFIP2
Gene Name cytoplasmic FMR1 interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000055163
Encoded Proteins
IDBP-366258
cytoplasmic FMR1 interacting protein 2
IDBP-473705
cytoplasmic FMR1 interacting protein 2
IDBP-482236
cytoplasmic FMR1 interacting protein 2
IDBP-482215
cytoplasmic FMR1 interacting protein 2
IDBP-810550
cytoplasmic FMR1 interacting protein 2
IDBP-603293
cytoplasmic FMR1 interacting protein 2
IDBP-810535
cytoplasmic FMR1 interacting protein 2
IDBP-810537
cytoplasmic FMR1 interacting protein 2
IDBP-810540
cytoplasmic FMR1 interacting protein 2
IDBP-810542
cytoplasmic FMR1 interacting protein 2
IDBP-810544
cytoplasmic FMR1 interacting protein 2
IDBP-810547
cytoplasmic FMR1 interacting protein 2
IDBP-810548
cytoplasmic FMR1 interacting protein 2
IDBP-810575
cytoplasmic FMR1 interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:157266079-157395598
Strand Forward strand
Band q33.3
Transcripts
ENST00000435847 ENSP00000403793
ENST00000522463 ENSP00000428009
ENST00000522637 ENSP00000428079
ENST00000521420 ENSP00000430904
ENST00000518456
ENST00000518511
ENST00000520942
ENST00000520960 ENSP00000482739
ENST00000518555
ENST00000520424
ENST00000522892
ENST00000523383
ENST00000524058
ENST00000519663
ENST00000522884
ENST00000522775
ENST00000541131 ENSP00000444645
ENST00000616178 ENSP00000479719
ENST00000620254 ENSP00000479968
ENST00000622696
ENST00000617629 ENSP00000480605
ENST00000611075 ENSP00000479376
ENST00000611925 ENSP00000478058
ENST00000618329 ENSP00000484819
ENST00000621516 ENSP00000479211
ENST00000620969 ENSP00000483307
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008009 chemokine activity
Biological Process
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0016337 single organismal cell-cell adhesion
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0045862 positive regulation of proteolysis
GO:0097202 activation of cysteine-type endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020340
View Gene Order
ENSBTAG00000008916
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa03013
RNA transport pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.519702 Hs.604735 Hs.608207
RefSeq NM_001037332 NM_001037333 NM_001291721 NM_014376
HUGO
OMIM
CCDS CCDS75364
HPRD 07556
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca