Version 5.4
Homo sapiens Gene: CTDP1
Summary
InnateDB Gene IDBG-5548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTDP1
Gene Name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Synonyms CCFDN; FCP1
Species Homo sapiens
Ensembl Gene ENSG00000060069
Encoded Proteins
IDBP-5550
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
IDBP-5552
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
IDBP-728139
IDBP-725686
IDBP-808397
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:79679801-79756623
Strand Forward strand
Band q23
Transcripts
ENST00000299543 ENSP00000299543
ENST00000075430 ENSP00000075430
ENST00000587623
ENST00000590599
ENST00000590635 ENSP00000467563
ENST00000591598 ENSP00000465119
ENST00000585951
ENST00000613122 ENSP00000484525
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
Experimentally validated
Total 59 [view]
Protein-Protein 58 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003899 DNA-directed RNA polymerase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0008420 CTD phosphatase activity
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006470 protein dephosphorylation
GO:0010458 exit from mitosis
GO:0010467 gene expression
GO:0016032 viral process
GO:0016311 dephosphorylation
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0015629 actin cytoskeleton
GO:0030496 midbody
GO:0051233 spindle midzone
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000033323
View Gene Order
Pathways
NETPATH
REACTOME
REACT_6344
Tat-mediated HIV elongation arrest and recovery pathway
REACT_6143
Pausing and recovery of Tat-mediated HIV elongation pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7EPW4
UniProt Splice Variant
Entrez Gene 9150
UniGene Hs.465490 Hs.734021
RefSeq NM_001202504 NM_004715 NM_048368 XM_005266782 XM_006722574
HUGO HGNC:2498
OMIM 604927
CCDS CCDS12017 CCDS12018 CCDS74239
HPRD 05377
IMGT
EMBL AC021594 AC068473
GenPept
RNA Seq Atlas 9150

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca