Homo sapiens Gene: MBD4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-55837.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MBD4 | ||||||||||||||||||
Gene Name | methyl-CpG binding domain protein 4 | ||||||||||||||||||
Synonyms | MED1 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000129071 | ||||||||||||||||||
Encoded Proteins |
methyl-CpG binding domain protein 4
methyl-CpG binding domain protein 4
methyl-CpG binding domain protein 4
methyl-CpG binding domain protein 4
methyl-CpG binding domain protein 4
methyl-CpG binding domain protein 4
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 3:129430944-129440179 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q21.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Displacement of DNA glycosylase by APE1 pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Cleavage of the damaged pyrimidine pathway
Removal of DNA patch containing abasic residue pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
Resolution of Abasic Sites (AP sites) pathway
Depyrimidination pathway
Base Excision Repair pathway
Base-Excision Repair, AP Site Formation pathway
DNA Repair pathway
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KEGG |
Base excision repair pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.35947 Hs.678717 Hs.692921 | ||||||||||||||||||
RefSeq | NM_001276270 NM_001276271 NM_001276272 NM_001276273 NM_003925 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS3058 CCDS63766 CCDS63767 CCDS63768 CCDS63769 | ||||||||||||||||||
HPRD | 04654 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||