InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTTG1

Summary

InnateDB Gene

IDBG-56181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTTG1

Gene Name

pituitary tumor-transforming 1

Synonyms

EAP1; HPTTG; PTTG; TUTR1

Species

Homo sapiens

Ensembl Gene

ENSG00000164611

Encoded Proteins

IDBP-56183

pituitary tumor-transforming 1

IDBP-242555

pituitary tumor-transforming 1

IDBP-480072

pituitary tumor-transforming 1

IDBP-474832

pituitary tumor-transforming 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008]
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:160421822-160428744

Strand

Forward strand

Band

q33.3

Transcripts

ENST00000352433	ENSP00000344936
ENST00000393964	ENSP00000377536
ENST00000524244
ENST00000517480	ENSP00000431068
ENST00000523659
ENST00000520452	ENSP00000430642
ENST00000519287

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	51 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007283	spermatogenesis
GO:0010951	negative regulation of endopeptidase activity
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051276	chromosome organization