InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WRNIP1

Summary

InnateDB Gene

IDBG-56442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WRNIP1

Gene Name

Werner helicase interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000124535

Encoded Proteins

IDBP-56444

Werner helicase interacting protein 1

IDBP-56446

Werner helicase interacting protein 1

IDBP-56448

Werner helicase interacting protein 1

IDBP-56450

Werner helicase interacting protein 1

IDBP-813122

Werner helicase interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:2765414-2786952

Strand

Forward strand

Band

p25.2

Transcripts

ENST00000380773	ENSP00000370150
ENST00000380771	ENSP00000370148
ENST00000380769	ENSP00000370146
ENST00000380764	ENSP00000370141
ENST00000618555	ENSP00000477551

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	34 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0030174	regulation of DNA-dependent DNA replication initiation

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021400

View Gene Order

ENSBTAG00000006166

Not yet available

Cross-References

SwissProt

Q96S55

TrEMBL

UniProt Splice Variant

Entrez Gene

56897

UniGene

Hs.236828

RefSeq

NM_020135 NM_130395 XM_005249232

HUGO

HGNC:20876

OMIM

608196

CCDS

CCDS4475 CCDS4476

HPRD

10494

IMGT

EMBL

AB056152 AB209723 AF218313 AK026179 AK223593 AK315471 AL139092 BC018923 CH471087

GenPept

AAF80563 AAH18923 BAB15383 BAB60709 BAD92960 BAD97313 BAG37857 CAH73663 CAH73664 CAH73665 CAH73666 EAW55087

RNA Seq Atlas

56897