InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FAU

Summary

InnateDB Gene

IDBG-56578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAU

Gene Name

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

Synonyms

asr1; FAU1; Fub1; Fubi; MNSFbeta; RPS30; S30

Species

Homo sapiens

Ensembl Gene

ENSG00000149806

Encoded Proteins

IDBP-56580

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-378152

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-589842

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-598546

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-588381

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-594988

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-586900

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

IDBP-595176

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65120628-65122473

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000279259	ENSP00000279259
ENST00000434372	ENSP00000413848
ENST00000529639	ENSP00000435370
ENST00000531743	ENSP00000431822
ENST00000525297	ENSP00000436110
ENST00000527548	ENSP00000434440
ENST00000531357
ENST00000529259	ENSP00000434680
ENST00000526555	ENSP00000433139

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002227	innate immune response in mucosa
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0008150	biological_process
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0019731	antibacterial humoral response
GO:0044267	cellular protein metabolic process
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005575	cellular_component
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit