Version 5.4
Homo sapiens Gene: HOXB13
Summary
InnateDB Gene IDBG-57015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXB13
Gene Name homeobox B13
Synonyms PSGD
Species Homo sapiens
Ensembl Gene ENSG00000159184
Encoded Proteins
IDBP-57017
homeobox B13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48724763-48729178
Strand Reverse strand
Band q21.32
Transcripts
ENST00000290295 ENSP00000290295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001525 angiogenesis
GO:0002009 morphogenesis of an epithelium
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008544 epidermis development
GO:0009611 response to wounding
GO:0033574 response to testosterone
GO:0040008 regulation of growth
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049604
View Gene Order
ENSBTAG00000014663
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q92826
TrEMBL
UniProt Splice Variant
Entrez Gene 10481
UniGene Hs.66731
RefSeq NM_006361
HUGO HGNC:5112
OMIM 604607
CCDS CCDS11536
HPRD
IMGT
EMBL AK313266 BC007092 BC070233 BT007410 CH471109 U57052 U81599
GenPept AAB39863 AAC50664 AAH07092 AAH70233 AAP36078 BAG36075 EAW94714
RNA Seq Atlas 10481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca