InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LCP2

Summary

InnateDB Gene

IDBG-57216.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCP2

Gene Name

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

Synonyms

SLP-76; SLP76

Species

Homo sapiens

Ensembl Gene

ENSG00000043462

Encoded Proteins

IDBP-57218

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

IDBP-478832

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

IDBP-474409

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25929249

[Mus musculus] Lcp2 is a critical determinant of natural killer (NK)-cell development and NK cell mediated elimination of missing-self target cells.

Entrez Gene

Summary

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72%% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:170246237-170298227

Strand

Reverse strand

Band

q35.1

Transcripts

ENST00000046794	ENSP00000046794
ENST00000520322
ENST00000521416	ENSP00000428871
ENST00000523369
ENST00000520344	ENSP00000430391
ENST00000519594
ENST00000522760
ENST00000522823
ENST00000519149

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045576	mast cell activation
GO:0050663	cytokine secretion
GO:0050852	T cell receptor signaling pathway