Version 5.4
Homo sapiens Gene: TCTN1
Summary
InnateDB Gene IDBG-57253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCTN1
Gene Name tectonic family member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204852
Encoded Proteins
IDBP-57255
tectonic family member 1
IDBP-234841
tectonic family member 1
IDBP-234845
tectonic family member 1
IDBP-234847
tectonic family member 1
IDBP-584623
tectonic family member 1
IDBP-807172
tectonic family member 1
IDBP-807199
tectonic family member 1
IDBP-807197
tectonic family member 1
IDBP-601847
tectonic family member 1
IDBP-807200
tectonic family member 1
IDBP-596618
tectonic family member 1
IDBP-590111
tectonic family member 1
IDBP-597755
tectonic family member 1
IDBP-590320
tectonic family member 1
IDBP-807198
tectonic family member 1
IDBP-589942
tectonic family member 1
IDBP-807170
tectonic family member 1
IDBP-807152
tectonic family member 1
IDBP-807220
tectonic family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:110614027-110649430
Strand Forward strand
Band q24.11
Transcripts
ENST00000377654 ENSP00000366882
ENST00000397659 ENSP00000380779
ENST00000397656 ENSP00000380776
ENST00000397655 ENSP00000380775
ENST00000490514 ENSP00000436044
ENST00000498072 ENSP00000474525
ENST00000471804 ENSP00000473903
ENST00000481720 ENSP00000474291
ENST00000495659 ENSP00000436673
ENST00000478122 ENSP00000474208
ENST00000464809 ENSP00000435027
ENST00000480648 ENSP00000437196
ENST00000482281
ENST00000463313
ENST00000460357
ENST00000485445
ENST00000491068
ENST00000481093
ENST00000552762
ENST00000551555
ENST00000547461 ENSP00000448188
ENST00000549123 ENSP00000450154
ENST00000552038
ENST00000547868
ENST00000546643 ENSP00000473743
ENST00000551590 ENSP00000448735
ENST00000552318 ENSP00000474343
ENST00000550703 ENSP00000473789
ENST00000614115 ENSP00000484255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001841 neural tube formation
GO:0008589 regulation of smoothened signaling pathway
GO:0021523 somatic motor neuron differentiation
GO:0021537 telencephalon development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021956 central nervous system interneuron axonogenesis
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0035869 ciliary transition zone
GO:0036038 TCTN-B9D complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038593
View Gene Order
ENSBTAG00000009208
Not yet available
Cross-References
SwissProt
TrEMBL E9PIB8 S4R3M8
UniProt Splice Variant
Entrez Gene 79600
UniGene Hs.211511 Hs.737105
RefSeq NM_001082537 NM_001082538 NM_001173975 NM_001173976 NM_024549 XM_005253936 XM_006719594 XM_006719596
HUGO HGNC:26113
OMIM 609863
CCDS CCDS41833 CCDS41834 CCDS41835
HPRD 08636
IMGT
EMBL AC002350 AC144522
GenPept
RNA Seq Atlas 79600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca