Version 5.4
Homo sapiens Gene: ATP5G1
Summary
InnateDB Gene IDBG-57292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5G1
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
Synonyms ATP5A; ATP5G
Species Homo sapiens
Ensembl Gene ENSG00000159199
Encoded Proteins
IDBP-57294
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
IDBP-243764
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
IDBP-475964
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
IDBP-475884
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
IDBP-482915
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
IDBP-762010
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48892765-48895871
Strand Forward strand
Band q21.32
Transcripts
ENST00000355938 ENSP00000348205
ENST00000393366 ENSP00000377033
ENST00000513347
ENST00000503641 ENSP00000426094
ENST00000514808 ENSP00000422086
ENST00000506855 ENSP00000422950
ENST00000513781
ENST00000504591 ENSP00000458423
ENST00000502964
ENST00000515060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008289 lipid binding
GO:0015078 hydrogen ion transmembrane transporter activity
Biological Process
GO:0015986 ATP synthesis coupled proton transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0016021 integral component of membrane
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006057
View Gene Order
ENSBTAG00000018339
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_6759
Formation of ATP by chemiosmotic coupling pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_17015
Metabolism of proteins pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.627037
RefSeq NM_001002027 NM_005175
HUGO
OMIM
CCDS CCDS11539
HPRD 04428
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca