InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYL2

Summary

InnateDB Gene

IDBG-57379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYL2

Gene Name

myosin, light chain 2, regulatory, cardiac, slow

Synonyms

CMH10; MLC2

Species

Homo sapiens

Ensembl Gene

ENSG00000111245

Encoded Proteins

IDBP-57381

myosin, light chain 2, regulatory, cardiac, slow

IDBP-596078

myosin, light chain 2, regulatory, cardiac, slow

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:110910819-110920722

Strand

Reverse strand

Band

q24.11

Transcripts

ENST00000228841	ENSP00000228841
ENST00000548438	ENSP00000447154
ENST00000549029
ENST00000546404

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003785	actin monomer binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0032036	myosin heavy chain binding

Biological Process

GO:0003007	heart morphogenesis
GO:0006942	regulation of striated muscle contraction
GO:0007507	heart development
GO:0009791	post-embryonic development
GO:0030049	muscle filament sliding
GO:0030308	negative regulation of cell growth
GO:0042694	muscle cell fate specification
GO:0048747	muscle fiber development
GO:0055003	cardiac myofibril assembly
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060047	heart contraction
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0031672	A band

Orthologs

No orthologs found for this gene

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

REACT_16969

Striated Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa04510

Focal adhesion pathway

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa04260

Cardiac muscle contraction pathway

hsa05414

Dilated cardiomyopathy pathway

INOH

PID NCI

thrombin_par1_pathway

PAR1-mediated thrombin signaling events

cdc42_pathway

CDC42 signaling events

thrombin_par4_pathway

PAR4-mediated thrombin signaling events

rhoa_pathway

RhoA signaling pathway

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

ncadherinpathway

N-cadherin signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000432

HUGO

OMIM

CCDS

CCDS31901

HPRD

01181

IMGT

EMBL

GenPept

RNA Seq Atlas