Homo sapiens Gene: MYL2
Summary
InnateDB Gene IDBG-57379.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol MYL2
Gene Name myosin, light chain 2, regulatory, cardiac, slow
Synonyms CMH10; MLC2;
Species Homo sapiens
Ensembl Gene ENSG00000111245
Encoded Proteins
myosin, light chain 2, regulatory, cardiac, slow
myosin, light chain 2, regulatory, cardiac, slow
myosin, light chain 2, regulatory, cardiac, slow
Protein Structure
Entrez Gene
Summary Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:111348638-111358526
Strand Reverse strand
Band q24.11
Transcripts
ENST00000228841 ENSP00000228841
ENST00000548438 ENSP00000447154
ENST00000550439 ENSP00000449490
ENST00000549029
ENST00000546404
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0032036 myosin heavy chain binding
Biological Process
GO:0003007 heart morphogenesis
GO:0006942 regulation of striated muscle contraction
GO:0007507 heart development
GO:0009791 post-embryonic development
GO:0030049 muscle filament sliding
GO:0030308 negative regulation of cell growth
GO:0042694 muscle cell fate specification
GO:0048747 muscle fiber development
GO:0055003 cardiac myofibril assembly
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0030017 sarcomere
Orthologs
No orthologs found for this gene
Pathways
NETPATH
TNFalpha pathway
REACTOME
Striated Muscle Contraction pathway
KEGG
Hypertrophic cardiomyopathy (HCM) pathway
Cardiac muscle contraction pathway
Dilated cardiomyopathy pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Tight junction pathway
Focal adhesion pathway
INOH
PID BIOCARTA
Rho cell motility signaling pathway [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Alk in cardiac myocytes [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
PID NCI
PAR1-mediated thrombin signaling events
CDC42 signaling events
PAR4-mediated thrombin signaling events
RhoA signaling pathway
Stabilization and expansion of the E-cadherin adherens junction
N-cadherin signaling events
Cross-References
SwissProt P10916
TrEMBL F8VWQ7 G3V1V8 Q6IB42 Q7Z3Z1
UniProt Splice Variant
Entrez Gene 4633
UniGene
RefSeq NM_000432
HUGO 7583
OMIM 160781
CCDS CCDS31901
HPRD 01181
IMGT
EMBL AC002351 AF020768 AK312013 BC015821 BC031006 BC031008 CH471054 CR456962 CR541957 M22815 S69022 X14332 X57542
GenPept AAA91832 AAB29658 AAB91993 AAH15821 AAH31006 AAH31008 BAG34951 CAA32510 CAA40761 CAG33243 CAG46755 EAW97943 EAW97944
ImmGen MYL2 (murine)
RNA Seq Atlas 4633