Version 5.4
Homo sapiens Gene: TLX3
Summary
InnateDB Gene IDBG-57439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLX3
Gene Name T-cell leukemia homeobox 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164438
Encoded Proteins
IDBP-57441
T-cell leukemia homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:171309284-171312134
Strand Forward strand
Band q35.1
Transcripts
ENST00000296921 ENSP00000296921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001708 cell fate specification
GO:0001764 neuron migration
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006355 regulation of transcription, DNA-templated
GO:0007417 central nervous system development
GO:0007585 respiratory gaseous exchange
GO:0030182 neuron differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0048665 neuron fate specification
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040610
View Gene Order
ENSBTAG00000010003
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.249125
RefSeq NM_021025
HUGO
OMIM
CCDS CCDS34288
HPRD 06868
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca