Version 5.4
Homo sapiens Gene: RTN2
Summary
InnateDB Gene IDBG-57622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN2
Gene Name reticulon 2
Synonyms NSP2; NSPL1; NSPLI; SPG12
Species Homo sapiens
Ensembl Gene ENSG00000125744
Encoded Proteins
IDBP-57624
reticulon 2
IDBP-57626
reticulon 2
IDBP-381960
reticulon 2
IDBP-761810
IDBP-765191
IDBP-761574
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45485289-45497061
Strand Reverse strand
Band q13.32
Transcripts
ENST00000344680 ENSP00000345127
ENST00000245923 ENSP00000245923
ENST00000430715 ENSP00000398178
ENST00000587597 ENSP00000468144
ENST00000590746
ENST00000588036
ENST00000591789
ENST00000593129
ENST00000591286 ENSP00000467863
ENST00000589628
ENST00000590526 ENSP00000466619
ENST00000593187
ENST00000592064
ENST00000589384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008219 cell death
GO:0046324 regulation of glucose import
GO:0065002 intracellular protein transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0014802 terminal cisterna
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030315 T-tubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030401
View Gene Order
ENSBTAG00000008185
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.47517
RefSeq NM_005619 NM_206900 NM_206901
HUGO
OMIM
CCDS CCDS12665 CCDS12666 CCDS46114
HPRD 04421
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca