Homo sapiens Gene: AUP1
Summary
InnateDB Gene IDBG-57682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AUP1
Gene Name ancient ubiquitous protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115307
Encoded Proteins
ancient ubiquitous protein 1
ancient ubiquitous protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74526645-74529939
Strand Reverse strand
Band p13.1
Transcripts
ENST00000377526 ENSP00000366748
ENST00000425118 ENSP00000403430
ENST00000463900
ENST00000466894
ENST00000486234
ENST00000462297
ENST00000464887
ENST00000472800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 43 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_181575
HUGO
OMIM
CCDS CCDS42702
HPRD 03892
IMGT
EMBL
GenPept
RNA Seq Atlas