Homo sapiens Gene: RNASEH2C

Summary
InnateDB Gene IDBG-57713.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol RNASEH2C
Gene Name ribonuclease H2, subunit C
Synonyms AGS3; AYP1
Species Homo sapiens
Ensembl Gene ENSG00000172922
Encoded Proteins
IDBP-57715 ribonuclease H2, subunit C
IDBP-585438 ribonuclease H2, subunit C
IDBP-587697 ribonuclease H2, subunit C
IDBP-585183 ribonuclease H2, subunit C
IDBP-602538 ribonuclease H2, subunit C
IDBP-602865 ribonuclease H2, subunit C
Entrez Gene
Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11: 65482367-65488418
Strand Reverse strand
Band q13.1
Transcripts
ENST00000308418  ENSP00000308193
ENST00000534482  ENSP00000432081
ENST00000533698  ENSP00000434996
ENST00000531596  ENSP00000435717
ENST00000528220  ENSP00000431555
ENST00000527610  ENSP00000432897
ENST00000530192 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein‑Protein  4
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000024925 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000005577 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa03030  DNA replication
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8TDP1 
TrEMBL E9PKP0 E9PN81
UniProt Splice Variant
Entrez Gene 84153 
UniGene Hs.718438
RefSeq NM_032193 
HUGO 24116 
OMIM 610330
CCDS CCDS8111 
HPRD 16531
IMGT
EMBL AF312034 AF346605 AF346606 AK024627 AP001266 BC023588
GenPept AAH23588  AAL87739  AAO49176  AAO49177  BAB14937 
ImmGen RNASEH2C (murine) 
RNA Seq Atlas 84153