Homo sapiens Gene: RNASEH2C
Summary
InnateDB Gene IDBG-57713.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol RNASEH2C
Gene Name ribonuclease H2, subunit C
Synonyms AGS3; AYP1;
Species Homo sapiens
Ensembl Gene ENSG00000172922
Encoded Proteins
ribonuclease H2, subunit C
ribonuclease H2, subunit C
ribonuclease H2, subunit C
ribonuclease H2, subunit C
ribonuclease H2, subunit C
ribonuclease H2, subunit C
Protein Structure
Entrez Gene
Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65482367-65488418
Strand Reverse strand
Band q13.1
Transcripts
ENST00000308418 ENSP00000308193
ENST00000534482 ENSP00000432081
ENST00000533698 ENSP00000434996
ENST00000531596 ENSP00000435717
ENST00000528220 ENSP00000431555
ENST00000527610 ENSP00000432897
ENST00000530192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8TDP1
TrEMBL E9PKP0 E9PN81
UniProt Splice Variant
Entrez Gene 84153
UniGene Hs.718438
RefSeq NM_032193
HUGO 24116
OMIM 610330
CCDS CCDS8111
HPRD 16531
IMGT
EMBL AF312034 AF346605 AF346606 AK024627 AP001266 BC023588
GenPept AAH23588 AAL87739 AAO49176 AAO49177 BAB14937
ImmGen RNASEH2C (murine)
RNA Seq Atlas 84153