InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CFL1

Summary

InnateDB Gene

IDBG-57818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFL1

Gene Name

cofilin 1 (non-muscle)

Synonyms

CFL; HEL-S-15

Species

Homo sapiens

Ensembl Gene

ENSG00000172757

Encoded Proteins

IDBP-57820

cofilin 1 (non-muscle)

IDBP-600967

cofilin 1 (non-muscle)

IDBP-601587

cofilin 1 (non-muscle)

IDBP-603158

cofilin 1 (non-muscle)

IDBP-589396

cofilin 1 (non-muscle)

IDBP-588120

cofilin 1 (non-muscle)

IDBP-601274

cofilin 1 (non-muscle)

IDBP-600549

cofilin 1 (non-muscle)

IDBP-596316

cofilin 1 (non-muscle)

IDBP-604000

cofilin 1 (non-muscle)

IDBP-588390

cofilin 1 (non-muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:65823022-65862026

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000308162	ENSP00000309629
ENST00000530157
ENST00000527752
ENST00000525710
ENST00000525451	ENSP00000432660
ENST00000530945
ENST00000527344	ENSP00000432155
ENST00000531407	ENSP00000433910
ENST00000524553	ENSP00000432226
ENST00000534769	ENSP00000431696
ENST00000531413	ENSP00000433131
ENST00000532134	ENSP00000436431
ENST00000530413	ENSP00000436899
ENST00000534784	ENSP00000433308
ENST00000526975	ENSP00000432153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	92 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001755	neural crest cell migration
GO:0001842	neural fold formation
GO:0002576	platelet degranulation
GO:0006468	protein phosphorylation
GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0009615	response to virus
GO:0022604	regulation of cell morphogenesis
GO:0030010	establishment of cell polarity
GO:0030036	actin cytoskeleton organization
GO:0030042	actin filament depolymerization
GO:0030168	platelet activation
GO:0030836	positive regulation of actin filament depolymerization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043066	negative regulation of apoptotic process
GO:0043200	response to amino acid
GO:0045087	innate immune response

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030864	cortical actin cytoskeleton
GO:0031258	lamellipodium membrane
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome