InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6V0E1

Summary

InnateDB Gene

IDBG-57918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0E1

Gene Name

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

Synonyms

ATP6H; ATP6V0E; M9.2; Vma21; Vma21p

Species

Homo sapiens

Ensembl Gene

ENSG00000113732

Encoded Proteins

IDBP-57920

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

IDBP-478719

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

IDBP-484667

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

IDBP-473784

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:172983757-173035445

Strand

Forward strand

Band

q35.1

Transcripts

ENST00000265093	ENSP00000265093
ENST00000519374	ENSP00000429690
ENST00000519911	ENSP00000430896
ENST00000517669	ENSP00000427941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0042625	ATPase activity, coupled to transmembrane movement of ions
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0007035	vacuolar acidification
GO:0008152	metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0016049	cell growth
GO:0033572	transferrin transport
GO:0043200	response to amino acid
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015575

View Gene Order

ENSBTAG00000015100

Not yet available

Pathways

NETPATH

REACTOME

REACT_25283

Transferrin endocytosis and recycling pathway

REACT_25060

Iron uptake and transport pathway

REACT_1109

Insulin receptor recycling pathway

REACT_498

Signaling by Insulin receptor pathway

REACT_121256

Phagosomal maturation (early endosomal stage) pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_111102

Signal Transduction pathway

REACT_121237

Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway

REACT_116125

Disease pathway

KEGG

hsa05110

Vibrio cholerae infection pathway

hsa05120

Epithelial cell signaling in Helicobacter pylori infection pathway

hsa00190

Oxidative phosphorylation pathway

hsa04966

Collecting duct acid secretion pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_003945

HUGO

OMIM

CCDS

CCDS4383

HPRD

04894

IMGT

EMBL

GenPept

RNA Seq Atlas