InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MRAS

Summary

InnateDB Gene

IDBG-58398.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRAS

Gene Name

muscle RAS oncogene homolog

Synonyms

M-RAs; R-RAS3; RRAS3

Species

Homo sapiens

Ensembl Gene

ENSG00000158186

Encoded Proteins

IDBP-58400

muscle RAS oncogene homolog

IDBP-384451

muscle RAS oncogene homolog

IDBP-478426

muscle RAS oncogene homolog

IDBP-478454

muscle RAS oncogene homolog

IDBP-483694

muscle RAS oncogene homolog

IDBP-475989

muscle RAS oncogene homolog

IDBP-808067

muscle RAS oncogene homolog

IDBP-808068

muscle RAS oncogene homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:138347648-138405534

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000289104	ENSP00000289104
ENST00000423968	ENSP00000389682
ENST00000494949	ENSP00000417685
ENST00000475711	ENSP00000417092
ENST00000464896	ENSP00000419582
ENST00000477784
ENST00000461114
ENST00000474559	ENSP00000418356
ENST00000478647
ENST00000621127	ENSP00000481637
ENST00000614350	ENSP00000484586

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007275	multicellular organismal development
GO:0007517	muscle organ development
GO:0015031	protein transport
GO:0030036	actin cytoskeleton organization

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032470

View Gene Order

ENSBTAG00000001497

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04010

MAPK signaling pathway pathway

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

O14807

TrEMBL

C9J601 C9J8Q6 Q6FGP0

UniProt Splice Variant

Entrez Gene

22808

UniGene

Hs.527021 Hs.605147

RefSeq

NM_012219 XM_005247228 XM_005247229 NM_001085049 NM_001252090 NM_001252091 NM_001252092 NM_001252093

HUGO

HGNC:7227

OMIM

608435

CCDS

CCDS3100 CCDS58855

HPRD

06662

IMGT

EMBL

AC022337 AC022497 AF022080 AF043938 AF493918 AK124954 AK295640 AK316071 BC047690 BT020057 CH471052 CR542067

GenPept

AAC52085 AAD02287 AAM12632 AAV38860 BAG54117 BAG58512 BAH14442 CAG46864 EAW79068 EAW79070 EAW79071

RNA Seq Atlas

22808