Version 5.4
Homo sapiens Gene: PGLYRP1
Summary
InnateDB Gene IDBG-58413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGLYRP1
Gene Name peptidoglycan recognition protein 1
Synonyms PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L
Species Homo sapiens
Ensembl Gene ENSG00000008438
Encoded Proteins
IDBP-58415
peptidoglycan recognition protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20418257
PGLYRP1 is a secreted innate immunity protein that is expressed in polymorphonuclear leukocytes and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.
PMID 21134971
PGLYRP1 is a peptidoglycan recognition protein and play a role in innate immunity against L. monocytogenes infection by inducing TNFA. (Demonstrated in murine model)
PMID 21439073
PGLYRP1 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
PMID 21602801
PGLYRP1 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals.
PMID 25595774
PGLYRP1 binds to bacterially derived peptidoglycan and these complexes constitute potent ligands capable of binding to TREM1 and inducing myeloid cell functions.
InnateDB Annotation from Orthologs
Summary
PMID 21134971
[Mus musculus] Pglyrp1 is a peptidoglycan recognition protein and play a role in innate immunity against L. monocytogenes infection by inducing Tnfa.
PMID 21439073
[Mus musculus] Pglyrp1 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
PMID 21602801
[Mus musculus] Pglyrp1 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals. (Demonstrated in human)
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46019153-46023065
Strand Reverse strand
Band q13.32
Transcripts
ENST00000008938 ENSP00000008938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016019 peptidoglycan receptor activity
GO:0042834 peptidoglycan binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006955 immune response
GO:0009253 peptidoglycan catabolic process
GO:0016045 detection of bacterium
GO:0032689 negative regulation of interferon-gamma production
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response
GO:0044117 growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030413
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt O75594
TrEMBL
UniProt Splice Variant
Entrez Gene 8993
UniGene Hs.137583
RefSeq NM_005091
HUGO HGNC:8904
OMIM 604963
CCDS CCDS12680
HPRD
IMGT
EMBL AC007785 AF076483 AF242517 AY358936 BC096154 BC096155 BC096156 BC096157 BC101845 BC101847
GenPept AAC31822 AAD38243 AAF99598 AAH96154 AAH96155 AAH96156 AAH96157 AAI01846 AAI01848 AAQ89295
RNA Seq Atlas 8993

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca