Version 5.4
Homo sapiens Gene: XYLT2
Summary
InnateDB Gene IDBG-58444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XYLT2
Gene Name xylosyltransferase II
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000015532
Encoded Proteins
IDBP-58446
xylosyltransferase II
IDBP-58448
xylosyltransferase II
IDBP-474318
xylosyltransferase II
IDBP-481116
xylosyltransferase II
IDBP-476883
xylosyltransferase II
IDBP-764528
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50346092-50363138
Strand Forward strand
Band q21.33
Transcripts
ENST00000017003 ENSP00000017003
ENST00000376550 ENSP00000365733
ENST00000509778 ENSP00000425511
ENST00000507602 ENSP00000426501
ENST00000511654 ENSP00000428350
ENST00000574840 ENSP00000460517
ENST00000571021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008375 acetylglucosaminyltransferase activity
GO:0030158 protein xylosyltransferase activity
Biological Process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030166 proteoglycan biosynthetic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030210 heparin biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020868
View Gene Order
ENSBTAG00000009298
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00532
Glycosaminoglycan biosynthesis pathway
hsa00534
Glycosaminoglycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463416
RefSeq NM_022167 XM_005257572
HUGO
OMIM
CCDS CCDS11563
HPRD 16286
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca