Version 5.4
Homo sapiens Gene: CNIH2
Summary
InnateDB Gene IDBG-58618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNIH2
Gene Name cornichon homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174871
Encoded Proteins
IDBP-58620
cornichon homolog 2 (Drosophila)
IDBP-602443
cornichon homolog 2 (Drosophila)
IDBP-600400
cornichon homolog 2 (Drosophila)
IDBP-583436
cornichon homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66278190-66285301
Strand Forward strand
Band q13.2
Transcripts
ENST00000311445 ENSP00000310003
ENST00000528852 ENSP00000432177
ENST00000534826 ENSP00000433896
ENST00000528063 ENSP00000435537
ENST00000530519
ENST00000531936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035249 synaptic transmission, glutamatergic
GO:0035556 intracellular signal transduction
GO:0042391 regulation of membrane potential
GO:0051668 localization within membrane
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024873
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437072
RefSeq NM_182553
HUGO
OMIM
CCDS CCDS8131
HPRD 13078
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca