Version 5.4
Homo sapiens Gene: FARS2
Summary
InnateDB Gene IDBG-58934.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FARS2
Gene Name phenylalanyl-tRNA synthetase 2, mitochondrial
Synonyms COXPD14; dJ520B18.2; FARS1; HSPC320; PheRS
Species Homo sapiens
Ensembl Gene ENSG00000145982
Encoded Proteins
IDBP-58936
phenylalanyl-tRNA synthetase 2, mitochondrial
IDBP-58938
phenylalanyl-tRNA synthetase 2, mitochondrial
IDBP-361251
phenylalanyl-tRNA synthetase 2, mitochondrial
IDBP-807647
phenylalanyl-tRNA synthetase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:5261044-5771580
Strand Forward strand
Band p25.1
Transcripts
ENST00000274680 ENSP00000274680
ENST00000324331 ENSP00000316335
ENST00000445533 ENSP00000392525
ENST00000602691 ENSP00000473394
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0008033 tRNA processing
GO:0010467 gene expression
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021420
View Gene Order
ENSBTAG00000018072
Not yet available
Pathways
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL R4GMX6
UniProt Splice Variant
Entrez Gene 10667
UniGene
RefSeq NM_006567 XM_005248811 XM_005248812
HUGO HGNC:21062
OMIM 611592
CCDS CCDS4494
HPRD
IMGT
EMBL AL021328 AL022097 AL121978 AL133473 AL392184 AL590868
GenPept
RNA Seq Atlas 10667

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca