InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BBC3

Summary

InnateDB Gene

IDBG-59341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BBC3

Gene Name

BCL2 binding component 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105327

Encoded Proteins

IDBP-59345

BCL2 binding component 3

IDBP-59347

BCL2 binding component 3

IDBP-382425

BCL2 binding component 3

IDBP-382426

BCL2 binding component 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:47220822-47232766

Strand

Reverse strand

Band

q13.32

Transcripts

ENST00000341983	ENSP00000341155
ENST00000300880	ENSP00000300880
ENST00000439096	ENSP00000395862
ENST00000449228	ENSP00000404503
ENST00000601438
ENST00000598636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	17 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0008340	determination of adult lifespan
GO:0032464	positive regulation of protein homooligomerization
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0034976	response to endoplasmic reticulum stress
GO:0043525	positive regulation of neuron apoptotic process
GO:0045926	negative regulation of growth
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070245	positive regulation of thymocyte apoptotic process
GO:0071456	cellular response to hypoxia
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001056	positive regulation of cysteine-type endopeptidase activity
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway