Homo sapiens Gene: SFTPB
InnateDB Gene IDBG-59448.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol SFTPB
Gene Name surfactant protein B
Synonyms PSP-B; SFTB3; SFTP3; SMDP1; SP-B;
Species Homo sapiens
Ensembl Gene ENSG00000168878
Encoded Proteins
surfactant protein B
surfactant protein B
surfactant protein B
surfactant protein B
surfactant protein B
Protein Structure
Entrez Gene
Summary This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85884437-85895864
Strand Reverse strand
Band p11.2
ENST00000342375 ENSP00000345161
ENST00000393822 ENSP00000377409
ENST00000409383 ENSP00000386346
ENST00000428225 ENSP00000415347
ENST00000519937 ENSP00000428719
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001666 response to hypoxia
GO:0006629 lipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0007585 respiratory gaseous exchange
GO:0007623 circadian rhythm
GO:0009749 response to glucose stimulus
GO:0009887 organ morphogenesis
GO:0032496 response to lipopolysaccharide
GO:0033189 response to vitamin A
GO:0051384 response to glucocorticoid stimulus
GO:0055093 response to hyperoxia
GO:0070741 response to interleukin-6
GO:0070849 response to epidermal growth factor stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005771 multivesicular body
GO:0042599 lamellar body
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
SwissProt P07988
UniProt Splice Variant
Entrez Gene 6439
UniGene Hs.512690 Hs.593933
RefSeq NM_000542 NM_198843
HUGO 10801
OMIM 178640
HPRD 01523
EMBL AC012454 AF400074 BC032785 CH471053 J02761 M16764 M19097 M24461
GenPept AAA36628 AAA60212 AAA88099 AAB59541 AAH32785 AAK77913 EAW99487 EAW99488 EAW99489
ImmGen SFTPB (murine)
RNA Seq Atlas 6439