Version 5.4
Homo sapiens Gene: FGFR4
Summary
InnateDB Gene IDBG-59460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFR4
Gene Name fibroblast growth factor receptor 4
Synonyms CD334; JTK2; TKF
Species Homo sapiens
Ensembl Gene ENSG00000160867
Encoded Proteins
IDBP-59462
fibroblast growth factor receptor 4
IDBP-243183
fibroblast growth factor receptor 4
IDBP-243185
fibroblast growth factor receptor 4
IDBP-381924
fibroblast growth factor receptor 4
IDBP-480104
fibroblast growth factor receptor 4
IDBP-477830
fibroblast growth factor receptor 4
IDBP-475953
fibroblast growth factor receptor 4
IDBP-482566
fibroblast growth factor receptor 4
IDBP-483131
fibroblast growth factor receptor 4
IDBP-479489
fibroblast growth factor receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177086886-177098144
Strand Forward strand
Band q35.2
Transcripts
ENST00000292408 ENSP00000292408
ENST00000393648 ENSP00000377259
ENST00000393637 ENSP00000377254
ENST00000430285 ENSP00000395164
ENST00000426612
ENST00000503708 ENSP00000424905
ENST00000514472 ENSP00000426492
ENST00000502906 ENSP00000424960
ENST00000510911 ENSP00000427222
ENST00000507708
ENST00000513166 ENSP00000422889
ENST00000509511
ENST00000508139
ENST00000511076 ENSP00000424670
ENST00000483872
ENST00000513423
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008201 heparin binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0001759 organ induction
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010715 regulation of extracellular matrix disassembly
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019216 regulation of lipid metabolic process
GO:0030324 lung development
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042593 glucose homeostasis
GO:0045087 innate immune response
GO:0045862 positive regulation of proteolysis
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048554 positive regulation of metalloenzyme activity
GO:0055062 phosphate ion homeostasis
GO:0061144 alveolar secondary septum development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070857 regulation of bile acid biosynthetic process
GO:2000188 regulation of cholesterol homeostasis
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005320
View Gene Order
ENSBTAG00000010543
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_21374
SHC-mediated cascade pathway
REACT_21270
PI-3K cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_111046
betaKlotho-mediated ligand binding pathway
REACT_9452
FGFR4 ligand binding and activation pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_121286
Signaling by FGFR4 mutants pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_111247
Klotho-mediated ligand binding pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_9396
FGFR ligand binding and activation pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa04144
Endocytosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt
TrEMBL D6R9V0 D6RG06 D6RJD4
UniProt Splice Variant
Entrez Gene 2264
UniGene
RefSeq NM_001291980 NM_002011 NM_022963 NM_213647 XM_005265837 XM_005265838
HUGO HGNC:3691
OMIM 134935
CCDS CCDS4410 CCDS4411
HPRD 00625
IMGT
EMBL AC027314
GenPept
RNA Seq Atlas 2264

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca