Version 5.4
Homo sapiens Gene: BMP6
Summary
InnateDB Gene IDBG-60018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP6
Gene Name bone morphogenetic protein 6
Synonyms VGR; VGR1
Species Homo sapiens
Ensembl Gene ENSG00000153162
Encoded Proteins
IDBP-60020
bone morphogenetic protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:7726797-7881422
Strand Forward strand
Band p24.3
Transcripts
ENST00000283147 ENSP00000283147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0046982 protein heterodimerization activity
GO:0070700 BMP receptor binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001822 kidney development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0003323 type B pancreatic cell development
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010039 response to iron ion
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014823 response to activity
GO:0030154 cell differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030539 male genitalia development
GO:0032026 response to magnesium ion
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0032526 response to retinoic acid
GO:0040007 growth
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0051216 cartilage development
GO:0051384 response to glucocorticoid
GO:0060395 SMAD protein signal transduction
GO:0071260 cellular response to mechanical stimulus
GO:2000105 positive regulation of DNA-dependent DNA replication
GO:2000860 positive regulation of aldosterone secretion
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039004
View Gene Order
ENSBTAG00000019234
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt P22004
TrEMBL B4DUF7
UniProt Splice Variant
Entrez Gene 654
UniGene Hs.285671
RefSeq NM_001718
HUGO HGNC:1073
OMIM 112266
CCDS CCDS4503
HPRD
IMGT
EMBL AK300628 AL133541 AL135778 M60315
GenPept AAA36737 BAG62319 CAI19426 CAI19472
RNA Seq Atlas 654

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca