Version 5.4
Homo sapiens Gene: NOG
Summary
InnateDB Gene IDBG-60160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOG
Gene Name noggin
Synonyms SYM1; SYNS1
Species Homo sapiens
Ensembl Gene ENSG00000183691
Encoded Proteins
IDBP-60162
noggin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:56593699-56595590
Strand Forward strand
Band q22
Transcripts
ENST00000332822 ENSP00000328181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001837 epithelial to mesenchymal transition
GO:0001839 neural plate morphogenesis
GO:0001843 neural tube closure
GO:0007389 pattern specification process
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0008045 motor neuron axon guidance
GO:0009953 dorsal/ventral pattern formation
GO:0010629 negative regulation of gene expression
GO:0021510 spinal cord development
GO:0021533 cell differentiation in hindbrain
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0035019 somatic stem cell maintenance
GO:0042060 wound healing
GO:0042474 middle ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0045596 negative regulation of cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048318 axial mesoderm development
GO:0048570 notochord morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048712 negative regulation of astrocyte differentiation
GO:0048762 mesenchymal cell differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051216 cartilage development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060173 limb development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060302 negative regulation of cytokine activity
GO:0060325 face morphogenesis
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060425 lung morphogenesis
GO:0060513 prostatic bud formation
GO:0060676 ureteric bud formation
GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0071773 cellular response to BMP stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090193 positive regulation of glomerulus development
GO:2000313 regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048616
View Gene Order
ENSBTAG00000040282
Not yet available
Pathways
NETPATH
REACTOME
REACT_12034
Signaling by BMP pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt Q13253
TrEMBL
UniProt Splice Variant
Entrez Gene 9241
UniGene Hs.248201
RefSeq NM_005450
HUGO HGNC:7866
OMIM 602991
CCDS CCDS11589
HPRD
IMGT
EMBL BC034027 U31202
GenPept AAA83259 AAH34027
RNA Seq Atlas 9241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca