Version 5.4
Homo sapiens Gene: ZIC4
Summary
InnateDB Gene IDBG-60236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZIC4
Gene Name Zic family member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174963
Encoded Proteins
IDBP-60238
Zic family member 4
IDBP-384751
Zic family member 4
IDBP-480294
Zic family member 4
IDBP-473455
Zic family member 4
IDBP-480645
Zic family member 4
IDBP-474171
Zic family member 4
IDBP-476338
Zic family member 4
IDBP-484890
Zic family member 4
IDBP-601618
Zic family member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:147386046-147406860
Strand Reverse strand
Band q24
Transcripts
ENST00000383075 ENSP00000372553
ENST00000425731 ENSP00000397695
ENST00000472749
ENST00000493664
ENST00000494569
ENST00000484399 ENSP00000417855
ENST00000473123 ENSP00000420775
ENST00000463850
ENST00000480015
ENST00000464502
ENST00000491672 ENSP00000418277
ENST00000475502
ENST00000462748 ENSP00000420627
ENST00000484586 ENSP00000418343
ENST00000463250 ENSP00000419727
ENST00000464144
ENST00000525172 ENSP00000435509
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036972
View Gene Order
ENSBTAG00000014749
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592576 Hs.690943 Hs.739084
RefSeq NM_001168378 NM_001168379 NM_001243256 NM_032153
HUGO
OMIM
CCDS CCDS43160 CCDS54652 CCDS54653 CCDS58857
HPRD 12340
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca