Version 5.4
Homo sapiens Gene: GGTLC1
Summary
InnateDB Gene IDBG-60385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGTLC1
Gene Name gamma-glutamyltransferase light chain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149435
Encoded Proteins
IDBP-60387
gamma-glutamyltransferase light chain 1
IDBP-60389
gamma-glutamyltransferase light chain 1
IDBP-60393
gamma-glutamyltransferase light chain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:23985050-23988779
Strand Reverse strand
Band p11.21
Transcripts
ENST00000335694 ENSP00000337587
ENST00000278765 ENSP00000278765
ENST00000286890 ENSP00000286890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0031362 anchored component of external side of plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9BX51
TrEMBL
UniProt Splice Variant
Entrez Gene 92086
UniGene Hs.355394
RefSeq NM_178311 NM_178312 XM_005260865 XM_006723662
HUGO HGNC:16437
OMIM 612338
CCDS CCDS13163
HPRD
IMGT
EMBL AL133466 BC040904 CH471133 L20491 L20492
GenPept AAA02885 AAA35864 AAH40904 CAC03399 EAX10125 EAX10129 EAX10130 EAX10131
RNA Seq Atlas 92086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca