Version 5.4
Homo sapiens Gene: DDX41
Summary
InnateDB Gene IDBG-60413.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX41
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183258
Encoded Proteins
IDBP-60415
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
IDBP-476793
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
IDBP-478838
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
IDBP-475136
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
IDBP-474990
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
IDBP-480119
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21892174
DDX41 is a helicase responsible for sensing intracellular DNA in myeloid dendritic cells. DDX41 expression knockdown blocked the induction of type I interferon and cytokine responses to DNA and DNA viruses. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 21892174
[Mus musculus] Ddx41 is a helicase responsible for sensing intracellular DNA in myeloid dendritic cells. Ddx41 expression knockdown blocked the induction of type I interferon and cytokine responses to DNA and DNA viruses.
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177511577-177517469
Strand Reverse strand
Band q35.3
Transcripts
ENST00000330503 ENSP00000330349
ENST00000512334
ENST00000507955 ENSP00000422753
ENST00000505081
ENST00000503078
ENST00000507900
ENST00000504807
ENST00000512027
ENST00000511040
ENST00000508279 ENSP00000421460
ENST00000513562
ENST00000512431
ENST00000504781 ENSP00000425739
ENST00000509576 ENSP00000426330
ENST00000506965
ENST00000515562
ENST00000510171 ENSP00000427082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 20 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006915 apoptotic process
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0035458 cellular response to interferon-beta
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021494
View Gene Order
ENSBTAG00000015187
Not yet available
Pathways
NETPATH
REACTOME
REACT_147841
STING mediated induction of host immune responses pathway
REACT_163993
IRF3-mediated induction of type I IFN pathway
REACT_6802
Innate Immune System pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_6900
Immune System pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_016222 XM_006714870
HUGO
OMIM
CCDS CCDS4427
HPRD 10490
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca