InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gm20390

Summary

InnateDB Gene

IDBG-605521.2

Last Modified

2013-04-25 [Report errors or provide feedback]

Gene Symbol

Gm20390

Gene Name

predicted gene 20390

Synonyms

NM23-H2; nm23-M2; NM23B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000091228

Encoded Proteins

IDBP-621654

non-metastatic cells 2, protein (NM23B) expressed in

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011052:
This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010] Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:93949819-93968293

Strand

Reverse strand

Band

Transcripts

ENSMUST00000170303

ENSMUSP00000132590

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0004673	protein histidine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0007229	integrin-mediated signaling pathway
GO:0018106	peptidyl-histidine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter