Homo sapiens Gene: MRPS5
Summary
InnateDB Gene IDBG-60952.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPS5
Gene Name mitochondrial ribosomal protein S5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144029
Encoded Proteins
mitochondrial ribosomal protein S5
mitochondrial ribosomal protein S5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:95087207-95149434
Strand Reverse strand
Band q11.1
Transcripts
ENST00000272418 ENSP00000272418
ENST00000345084 ENSP00000341660
ENST00000482821
ENST00000461916
ENST00000482568
ENST00000475895
ENST00000464458
ENST00000475040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655259
RefSeq NM_031902
HUGO
OMIM
CCDS CCDS2010
HPRD 10099
IMGT
EMBL
GenPept
RNA Seq Atlas