Homo sapiens Gene: FGF21
Summary
InnateDB Gene IDBG-61149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF21
Gene Name fibroblast growth factor 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105550
Encoded Proteins
fibroblast growth factor 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48755559-48758330
Strand Forward strand
Band q13.33
Transcripts
ENST00000222157 ENSP00000222157
ENST00000593756 ENSP00000471477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Melanoma pathway
INOH
GPCR signaling pathway
FGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.283015 Hs.735856
RefSeq NM_019113 XM_005258731
HUGO
OMIM
CCDS CCDS12734
HPRD 09447
IMGT
EMBL
GenPept
RNA Seq Atlas