InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LRP5

Summary

InnateDB Gene

IDBG-61383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRP5

Gene Name

low density lipoprotein receptor-related protein 5

Synonyms

BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP7; OPPG; OPS; OPTA1; VBCH2

Species

Homo sapiens

Ensembl Gene

ENSG00000162337

Encoded Proteins

IDBP-61387

low density lipoprotein receptor-related protein 5

IDBP-591577

low density lipoprotein receptor-related protein 5

IDBP-600618

low density lipoprotein receptor-related protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq, Nov 2009]
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68312609-68449275

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000294304	ENSP00000294304
ENST00000529993	ENSP00000436652
ENST00000528890
ENST00000528714
ENST00000533695
ENST00000529702	ENSP00000435315
ENST00000529481

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0017147	Wnt-protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0001944	vasculature development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002076	osteoblast development
GO:0006007	glucose catabolic process
GO:0006897	endocytosis
GO:0008203	cholesterol metabolic process
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0016055	Wnt signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0033690	positive regulation of osteoblast proliferation
GO:0035019	somatic stem cell maintenance
GO:0035108	limb morphogenesis
GO:0035426	extracellular matrix-cell signaling
GO:0042074	cell migration involved in gastrulation
GO:0042632	cholesterol homeostasis
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045600	positive regulation of fat cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045840	positive regulation of mitosis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046849	bone remodeling
GO:0046850	regulation of bone remodeling
GO:0048539	bone marrow development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060033	anatomical structure regression
GO:0060042	retina morphogenesis in camera-type eye
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060070	canonical Wnt signaling pathway
GO:0060348	bone development
GO:0060349	bone morphogenesis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060603	mammary gland duct morphogenesis
GO:0060612	adipose tissue development
GO:0060764	cell-cell signaling involved in mammary gland development
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061304	retinal blood vessel morphogenesis
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902262	apoptotic process involved in patterning of blood vessels