Version 5.4
Homo sapiens Gene: PYGB
Summary
InnateDB Gene IDBG-61441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYGB
Gene Name phosphorylase, glycogen; brain
Synonyms GPBB
Species Homo sapiens
Ensembl Gene ENSG00000100994
Encoded Proteins
IDBP-61443
phosphorylase, glycogen; brain
IDBP-369874
phosphorylase, glycogen; brain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:25248069-25298014
Strand Forward strand
Band p11.21
Transcripts
ENST00000216962 ENSP00000216962
ENST00000428458 ENSP00000395451
ENST00000471359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004645 phosphorylase activity
GO:0008184 glycogen phosphorylase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005980 glycogen catabolic process
GO:0006006 glucose metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000033059
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_1008
Glycogen breakdown (glycogenolysis) pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa00500
Starch and sucrose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368157 Hs.657463 Hs.730268
RefSeq NM_002862 XM_006723601
HUGO
OMIM
CCDS CCDS13171
HPRD 00720
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca