Version 5.4
Homo sapiens Gene: ANAPC5
Summary
InnateDB Gene IDBG-61638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANAPC5
Gene Name anaphase promoting complex subunit 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089053
Encoded Proteins
IDBP-61640
anaphase promoting complex subunit 5
IDBP-384420
anaphase promoting complex subunit 5
IDBP-591113
anaphase promoting complex subunit 5
IDBP-601195
anaphase promoting complex subunit 5
IDBP-599335
anaphase promoting complex subunit 5
IDBP-584709
anaphase promoting complex subunit 5
IDBP-600708
anaphase promoting complex subunit 5
IDBP-589584
anaphase promoting complex subunit 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:121308245-121399896
Strand Reverse strand
Band q24.31
Transcripts
ENST00000261819 ENSP00000261819
ENST00000366333
ENST00000422342
ENST00000441917 ENSP00000415061
ENST00000535641
ENST00000539079 ENSP00000437857
ENST00000534976
ENST00000541887 ENSP00000439875
ENST00000535482 ENSP00000438754
ENST00000545218
ENST00000535472
ENST00000538334
ENST00000535463
ENST00000538223
ENST00000539612
ENST00000541652
ENST00000544442 ENSP00000440800
ENST00000536416
ENST00000539871 ENSP00000445191
ENST00000536837 ENSP00000441508
ENST00000545801
ENST00000544314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
Experimentally validated
Total 87 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000090 mitotic anaphase
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007067 mitotic nuclear division
GO:0007094 mitotic spindle assembly checkpoint
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029472
View Gene Order
ENSBTAG00000003092
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6904
Phosphorylation of the APC/C pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120956
Cellular responses to stress pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.690132 Hs.7101
RefSeq NM_001137559 NM_016237 XM_005253900 XM_006719449
HUGO
OMIM
CCDS CCDS45000 CCDS9220
HPRD 10453
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca