Homo sapiens Gene: PIGO
Summary
InnateDB Gene IDBG-61777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGO
Gene Name phosphatidylinositol glycan anchor biosynthesis, class O
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165282
Encoded Proteins
phosphatidylinositol glycan anchor biosynthesis, class O
phosphatidylinositol glycan anchor biosynthesis, class O
phosphatidylinositol glycan anchor biosynthesis, class O
Protein Structure
Entrez Gene
Summary This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35088688-35096601
Strand Reverse strand
Band p13.3
Transcripts
ENST00000298004 ENSP00000298004
ENST00000378617 ENSP00000367880
ENST00000361778 ENSP00000354678
ENST00000474436
ENST00000465745
ENST00000491687
ENST00000472208
ENST00000492770
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008484 sulfuric ester hydrolase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0008152 metabolic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational modification: synthesis of GPI-anchored proteins pathway
Post-translational protein modification pathway
Synthesis of glycosylphosphatidylinositol (GPI) pathway
Metabolism of proteins pathway
KEGG
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8TEQ8
TrEMBL
UniProt Splice Variant
Entrez Gene 84720
UniGene Hs.522099 Hs.735712
RefSeq NM_001201484 NM_032634 NM_152850 XM_005251619
HUGO HGNC:23215
OMIM 614730
CCDS CCDS6575 CCDS6576
HPRD 15134
IMGT
EMBL AB083625 AC004472 AK074064 AK090433 AL353795 AL833956 AY358472 BC001030 BC013987 BC029271 BC036916 BC065282 CH471071
GenPept AAC07985 AAH01030 AAH13987 AAH29271 AAH36916 AAH65282 AAQ88836 BAB84890 BAB89338 BAC03414 CAD38806 CAH70995 CAH70996 EAW58397
ImmGen PIGO (murine)
RNA Seq Atlas 84720