Version 5.4
Homo sapiens Gene: UXT
Summary
InnateDB Gene IDBG-61973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UXT
Gene Name ubiquitously-expressed, prefoldin-like chaperone
Synonyms ART-27; STAP1
Species Homo sapiens
Ensembl Gene ENSG00000126756
Encoded Proteins
IDBP-61975
ubiquitously-expressed transcript
IDBP-61977
ubiquitously-expressed transcript
IDBP-807904
ubiquitously-expressed, prefoldin-like chaperone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47651798-47659161
Strand Reverse strand
Band p11.23
Transcripts
ENST00000333119 ENSP00000327797
ENST00000335890 ENSP00000337393
ENST00000376964
ENST00000460840
ENST00000485641 ENSP00000473785
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 31 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0048487 beta-tubulin binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000226 microtubule cytoskeleton organization
GO:0006351 transcription, DNA-templated
GO:0006457 protein folding
GO:0047497 mitochondrion transport along microtubule
GO:0051297 centrosome organization
Cellular Component
GO:0000930 gamma-tubulin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0016272 prefoldin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001134
View Gene Order
ENSBTAG00000015820
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004182 NM_153477
HUGO
OMIM
CCDS CCDS14284 CCDS14285
HPRD 02209
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca