Version 5.4
Homo sapiens Gene: SPAG6
Summary
InnateDB Gene IDBG-61993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG6
Gene Name sperm associated antigen 6
Synonyms CT141; pf16; Repro-SA-1
Species Homo sapiens
Ensembl Gene ENSG00000077327
Encoded Proteins
IDBP-61995
sperm associated antigen 6
IDBP-61997
sperm associated antigen 6
IDBP-61999
sperm associated antigen 6
IDBP-369257
sperm associated antigen 6
IDBP-369258
sperm associated antigen 6
IDBP-593415
sperm associated antigen 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:22345445-22454224
Strand Forward strand
Band p12.2
Transcripts
ENST00000376624 ENSP00000365811
ENST00000376603 ENSP00000365788
ENST00000313311 ENSP00000323599
ENST00000456231 ENSP00000411111
ENST00000435326 ENSP00000406594
ENST00000488555
ENST00000490361
ENST00000487973
ENST00000538630 ENSP00000441325
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0007286 spermatid development
GO:0030030 cell projection organization
Cellular Component
GO:0005634 nucleus
GO:0005874 microtubule
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022783
View Gene Order
ENSBTAG00000033291
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001253854 NM_001253855 NM_012443 NM_172242 XM_005252645
HUGO
OMIM
CCDS CCDS58071 CCDS7139 CCDS7140 CCDS73072
HPRD 09305
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca