Version 5.4
Homo sapiens Gene: MAPK9
Summary
InnateDB Gene IDBG-62183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK9
Gene Name mitogen-activated protein kinase 9
Synonyms JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a
Species Homo sapiens
Ensembl Gene ENSG00000050748
Encoded Proteins
IDBP-62185
mitogen-activated protein kinase 9
IDBP-62187
mitogen-activated protein kinase 9
IDBP-236162
mitogen-activated protein kinase 9
IDBP-243770
mitogen-activated protein kinase 9
IDBP-243772
mitogen-activated protein kinase 9
IDBP-382699
mitogen-activated protein kinase 9
IDBP-382700
mitogen-activated protein kinase 9
IDBP-382703
mitogen-activated protein kinase 9
IDBP-482794
mitogen-activated protein kinase 9
IDBP-591161
mitogen-activated protein kinase 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19153595
MAPK9 phosphorylates IRF3 and is essential for IRF3 dimerization induced by polyinosinic-cytidylic acid (polyI:C).
PMID 24651600
Upon viral infection, MAVS recruits MKK7 onto mitochondria, leading to the induction of apoptosis by MAP2K7 activated MAPK9
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene\'s mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:180233143-180292099
Strand Reverse strand
Band q35.3
Transcripts
ENST00000347470 ENSP00000321410
ENST00000343111 ENSP00000345524
ENST00000397072 ENSP00000380262
ENST00000393362 ENSP00000377029
ENST00000393360 ENSP00000377028
ENST00000455781 ENSP00000389338
ENST00000452135 ENSP00000394560
ENST00000425491 ENSP00000397422
ENST00000520212
ENST00000524170
ENST00000523135
ENST00000523583 ENSP00000430608
ENST00000539014 ENSP00000443149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 129 [view]
Protein-Protein 127 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0001836 release of cytochrome c from mitochondria
GO:0001934 positive regulation of protein phosphorylation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006626 protein targeting to mitochondrion
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006950 response to stress
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0007417 central nervous system development
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0014075 response to amine
GO:0016310 phosphorylation
GO:0031175 neuron projection development
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031396 regulation of protein ubiquitination
GO:0032308 positive regulation of prostaglandin secretion
GO:0032722 positive regulation of chemokine production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0034644 cellular response to UV
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046328 regulation of JNK cascade
GO:0046686 response to cadmium ion
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020366
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_21368
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_120956
Cellular responses to stress pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05212
Pancreatic cancer pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
atf2_pathway
ATF-2 transcription factor network
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL D7R528
UniProt Splice Variant
Entrez Gene 5601
UniGene Hs.484371 Hs.694868
RefSeq NM_001135044 NM_002752 NM_139068 NM_139069 NM_139070 XM_006714891
HUGO HGNC:6886
OMIM 602896
CCDS CCDS43409 CCDS43410 CCDS4453 CCDS4454 CCDS47356
HPRD 04206
IMGT
EMBL AC008610 AC104115 HM036709
GenPept ADH10368
RNA Seq Atlas 5601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca